Not sure if this has been posted previously, but it seems that sometimes games/applications can get muted from desktop mode. I

I launched Persona 5 Royal this morning and was surprised to see the audio not working. After doing many things such as trying different layers of proton, I went into desktop mode and saw that the game had been muted. After un-muting it, it works again. I do play Persona 5 in desktop mode sometimes when I feel like streaming it for some friends to watch. But I’d never run into this muting issue before. I must have pressed something and it made some combination that would mute the ‘application.’

Anyhow, everything works fine now. Hope this helps someone.

TLDR; Games might get muted from desktop mode. If audio isn’t working in a game you are playing, go into desktop mode and launch the game. Then click on the sound icon and look under applications to see if the game has indeed been muted.