Our News Team @ 11 with host Snot Flickerman

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Joined 11 months ago
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Cake day: October 24th, 2023

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  • So the CBD thing really bugs me, in particular.

    One of my medications has one of those warnings about how you can’t have grapefruit while taking this medication. That’s because grapefruit is metabolized on a certain enzyme pathway that gets interrupted. That enzyme pathway is CYP3A4.

    You know what else takes that enzyme pathway? Fucking CBD. It also blocks the enzyme pathway, making any drugs administered less effective because they can’t bind to where they need to because the CBD molecule is already there, taking up space.

    So like, for me, these are life saving medications so fucking around with this is really stupid but literally no doctor told me this. I accidentally figured this out while doing research on CBD. It seems like its becoming more publicized now, but the bottom line is this:

    If you have medication that warns you that you should not eat grapefruit with this medication (about 60% of medications, I believe), that medication needs the same warning about CBD.

    https://www.pharmacytimes.com/view/cannabidiol-presents-conundrums

    Upon further evaluation, it was shown that CYP3A4 and CYP2C19 are the 2 major enzymes responsible for the metabolism of CBD; they are also responsible for the metabolism of many different drugs.







  • Here’s hoping they stick this time. I’m so sorry to hear, long ago one of my now ex-girlfriends was dealing with it. She would have to go to the hospital and get GI cocktails and I would stay awake with her and try to help her not panic because the GI cocktail numbed everything in your throat and she wouldn’t be able to feel herself breathing. As someone who has lots of panic about breathing issues, I totally understood why it would be panic inducing to not be able to feel yourself breathe, and this seemed like the only thing anyone was able to do for her when it got really bad. Just a shitty choice, take the GI cocktail and get relief but also panic, or don’t take it and feel like you’re choking on your own vomit. So , fuck it just sucks so much. I really hope for the best for you.