It’s doable and although I would best describe the dev experience as “ok”, it is improving over time.

Per your bullets

• use newer module based js libraries, yes this is limiting but getting better support over time, and you still have to deal with issues cause by different library types when using a bundler

• JSX will require a build step at some point, pushing that to runtime doesn’t improve anything. Instead I would favor lit html

• probably true, but I would start without and wrap a bundler around the project when it becomes necessary, smaller projects will have a negligible effect. You should benchmark the differences yourself, and if you use es modules everywhere wrapping a bundler around it will be easy.

With the above you can get all the usual niceties too: hot reloading, lazy loading, etc

Complex software for developing, video and graphics editing, and CAD all have very capable web stack counterparts to the usual desktop applications. vscode, Canva, photopea, onshape, etc